PIGEON DROP

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Published online Apr Author information Article notes Copyright and License information Disclaimer. Corresponding author.

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Received Oct 29; Accepted Apr Additional file 2: Figure S2. Additional file 3: Figure S3. Abstract Background Avian antigen is a common cause of hypersensitivity pneumonitis HP. Method Pigeon serum, pigeon intestine homogenates, and PDE were immunoblotted with serum samples from 8 patients with BRHP, 2 patients with summer-type HP, 2 patients with humidifier lung, and 3 healthy volunteers. Electronic supplementary material The online version of this article doi Keywords: Hypersensitivity pneumonitis, Extrinsic allergic alveolitis, Bird, Pigeon, Antigen, Protein of immunoglobulin-superfamily.

Background Hypersensitivity pneumonitis HP is an allergic lung disease caused by repeated inhalation of causative antigens.

Materials Pigeon serum was collected from veins under the wings and cardiac punctures of five pigeons and pooled. Statistical analysis All values were analyzed using GraphPad Prism ver 5. Open in a separate window. Table 1 Characteristics of subject groups. Additional files Additional file 1: 85K, pptx Figure S1.

Additional file 2: K, pptx Figure S2.


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Additional file 3: 89K, pptx Figure S3. Acknowledgements We thank all of the members of the Department of Human Pathology of Tokyo Medical and Dental University; Takashige Suzuki for his help in collecting the pigeon samples; Takeshi Kasama for performing the protein identification by mass spectrometry; Arisa Kaino, Takehiro Yamamoto, Katsuhiro Sato, and Ayaka Matsukaze for their assistance; and all of the patients and volunteers who donated blood for this study.

Availability of data and materials Please contact author for data requests. Competing interests None declared. Consent for publication Not applicable. References 1. Selman M. Hypersensitivity pneumonitis.

3. The Pigeon Drop

Interstitial lung disease. Classification of hypersensitivity pneumonitis: a hypothesis. Int Arch Allergy Immunol. Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. Respir Investig. Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study. Lancet Respir Med. J Lab Clin Med. Ann Allergy Asthma Immunol. Validation of inhalation provocation test in chronic bird-related hypersensitivity pneumonitis and new prediction score.


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  8. Ann Am Thorac Soc. Schuyler M, Cormier Y. The diagnosis of hypersensitivity pneumonitis. Chronic hypersensitivity pneumonitis in Japan: a nationwide epidemiologic survey. J Allergy Clin Immunol. J Reticuloendothel Soc. Differences in the immune responses of pigeon breeders to pigeon serum proteins.


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    Isolation and characterization of antigen PDE1. Int Arch Allergy Appl Immunol. Immunol Commun. Z Immunitatsforsch Immunobiol. Longbottom JL. Clin Exp Allergy. A review of antigen diversity causing lung disease among pigeon breeders. The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J Exp Med. Three-dimensional modeling of a pre-B-cell receptor. Mol Immunol.